In contrast to the successful previous year, 2020 turned out to be difficult, not only for the earth’s population due to COVID-19 but also for JDDM with an unusually small sixth volume. Looking back at these two very different years back-to-back led us to some reflection: As the COVID-19 pandemic forcefully illustrates, dynamic decision-making with all its complications and uncertainty is a topic of high relevance for modern societies.

The Protein Ontology (PRO) web resource provides an integrative framework for protein-centric exploration and enables specific and precise annotation of proteins and protein complexes based on PRO. Functionalities include: browsing, searching and retrieving, terms, displaying selected terms in OBO or OWL format, and supporting URIs. In addition, the PRO website offers multiple ways for the user to request, submit, or modify terms and/or annotation. We will demonstrate the use of these tools for protein research and annotation.

The Cell Ontology (CL) is designed to provide a standardized representation of cell types for data annotation. Currently, the CL employs multiple is_a relations, defining cell types in terms of histological, functional, and lineage properties, and the majority of definitions are written with sufficient generality to hold across multiple species. This approach limits the CL’s utility for cross-species data integration. To address this problem, we developed a method for the ontological representation of cells and applied this method to develop a (...) dendritic cell ontology (DC-CL). DC-CL subtypes are delineated on the basis of surface protein expression, systematically including both species-general and species-specific types and optimizing DC-CL for the analysis of flow cytometry data. This approach brings benefits in the form of increased accuracy, support for reasoning, and interoperability with other ontology resources. 104. Barry Smith, “Toward a Realistic Science of Environments”, Ecological Psychology, 2009, 21 (2), April-June, 121-130. Abstract: The perceptual psychologist J. J. Gibson embraces a radically externalistic view of mind and action. We have, for Gibson, not a Cartesian mind or soul, with its interior theater of contents and the consequent problem of explaining how this mind or soul and its psychological environment can succeed in grasping physical objects external to itself. Rather, we have a perceiving, acting organism, whose perceptions and actions are always already tuned to the parts and moments, the things and surfaces, of its external environment. We describe how on this basis Gibson sought to develop a realist science of environments which will be ‘consistent with physics, mechanics, optics, acoustics, and chemistry’. (shrink)

The Protein Ontology (PRO; http://proconsortium.org) formally defines protein entities and explicitly represents their major forms and interrelations. Protein entities represented in PRO corresponding to single amino acid chains are categorized by level of specificity into family, gene, sequence and modification metaclasses, and there is a separate metaclass for protein complexes. All metaclasses also have organism-specific derivatives. PRO complements established sequence databases such as UniProtKB, and interoperates with other biomedical and biological ontologies such as the Gene Ontology (GO). PRO relates to (...) UniProtKB in that PRO’s organism-specific classes of proteins encoded by a specific gene correspond to entities documented in UniProtKB entries. PRO relates to the GO in that PRO’s representations of organism-specific protein complexes are subclasses of the organism-agnostic protein complex terms in the GO Cellular Component Ontology. The past few years have seen growth and changes to the PRO, as well as new points of access to the data and new applications of PRO in immunology and proteomics. Here we describe some of these developments. (shrink)

The Protein Ontology (PRO; http://purl.obolibrary.org/obo/pr) formally defines and describes taxon-specific and taxon-neutral protein-related entities in three major areas: proteins related by evolution; proteins produced from a given gene; and protein-containing complexes. PRO thus serves as a tool for referencing protein entities at any level of specificity. To enhance this ability, and to facilitate the comparison of such entities described in different resources, we developed a standardized representation of proteoforms using UniProtKB as a sequence reference and PSI-MOD as a post-translational modification (...) reference. We illustrate its use in facilitating an alignment between PRO and Reactome protein entities. We also address issues of scalability, describing our first steps into the use of text mining to identify protein-related entities, the large-scale import of proteoform information from expert curated resources, and our ability to dynamically generate PRO terms. Web views for individual terms are now more informative about closely-related terms, including for example an interactive multiple sequence alignment. Finally, we describe recent improvement in semantic utility, with PRO now represented in OWL and as a SPARQL endpoint. These developments will further support the anticipated growth of PRO and facilitate discoverability of and allow aggregation of data relating to protein entities. (shrink)

This chapter sheds light on a response to experimental philosophy that has not yet received enough attention: the reflection defense. According to proponents of this defense, judgments about philosophical cases are relevant only when they are the product of careful, nuanced, and conceptually rigorous reflection. The chapter argues that the reflection defense is misguided: Five studies (N>1800) are presented, showing that people make the same judgments when they are primed to engage in careful reflection as they do in the conditions (...) standardly used by experimental philosophers. (shrink)

We present a vignette study conducted with a quota sample of the German population (n = 400). Subjects had to redistribute a good between two hypothetical persons who contributed equally to the available amount but differed in quantity needed and the reason for their neediness. On a within-subjects level, we tested for the effects of need, accountability, and resource availability on their third-party distribution decisions. Between subjects, we further varied the kinds of needs: The persons either needed the good as (...) a means to survive, to live a decent life, to participate in society, or to be autonomous. Despite equal productivity, the mean share allocated to the needier person was significantly higher than an equal share. However, this share turned out significantly smaller when the needier person was accountable for needing more than the other. Nonetheless, even if accountable, the needier person still got a share larger than their contribution would suggest. When there was a surplus of resources, the needier person got an even higher share than when resources were scarce. (shrink)

Bilim ve din arasındaki etkileşimler hem tarihsel olarak hem de günümüzde çeşitli ve karmaşıktır. Modeller, verileri anlamlandırmak için faydalı olabilir. Bu makale, bilim-din etkileşimlerini tanımlamak için önerilen dört ana model türünü karşılaştırarak, onların güçlü ve zayıf yönlerini vurgulamaktadır. Bilimsel ve dini bilgiyi ilişkilendirme görevinde 'bütünleyici' modelin en verimli olduğu sonucuna varılmıştır.

Paul Goodman, 1960’larda modern Amerikan toplumunun organize sistemi içerisinde dönemin gençliğinin sorunlarını ön plana çıkaran ‘Growing Up Absurd: Problems of Youth in the Organized System’ (Saçmayı Büyütmek: Organize Sistemde Gençliğin Problemleri, 1960) eseri ile sosyal bir eleştirmen olarak ön plana çıkmıştır. Amerikalı bir düşünür olan Paul Goodman’ın kısa öyküler, romanlar, şiirler ve makalelerden oluşan çalışmaları, siyaset, sosyal teori, eğitim, kentsel tasarım, edebi eleştiri, hatta psikoterapi gibi geniş bir yelpazeye dağılmıştır. Onun temel argümanı (1960: 9-10) tek bir merkez etrafında örgütlenen teknoloji (...) toplumunun başarısızlıklarını eleştirerek, mevcut düzenin insanın doğasına uygun bir biçimde yeniden inşasını vurgulamaktadır. Goodman’ın yeniden inşa süreci içerisinde insan doğasına önem veren faaliyete dayalı anarşist ideolojisi, sorumluluk duygusunun homojen bir şekilde bireyler arasında paylaşılması gerektiğini vurgular. Goodman merkeziyetçi olmayan siyaset anlayışı ile kendisini Amerikan siyasetinin ve kültürünün karşısında yer alan bir pozisyonda konumlandırmaktadır (Honeywell, 2011: 1). Diğer bir deyişle Goodman (1960: 36), anarşist geleneği formüle etmek amacıyla yirminci yüzyıl Amerikası’nın içinde bulunmuş olduğu mevcut durumdan yola çıkarak eleştirilerini ademi merkeziyetçilik, katılımcı demokrasi, özerk toplum temaları üzerine temellendirmiştir. -/- Goodman’a göre, sosyal, kültürel, ahlâk ve eğitim gibi alanlarda uygulanan kurallar günümüz devletlerini etkisi altına alan kapitalist düzen tarafından belirlenmektedir (Bakır, 2016: 110). Bu durum Goodman’ın da içerisinde bulunduğu anarşist düşünürler tarafından kabul edilebilecek bir husus değildir, çünkü anarşistler mevcut düzenin ve sosyal yaşamın otorite ve itaat yapılarıyla güçlendirilen belirli yaklaşımlar ile kontrol altına alınmasını, insanların fikirlerini özgürce ifade edemeyeceği, bir nevi entelektüel bir hapishane içerisinde yaşaması anlamına geleceğinden dolayı karşı çıkmaktadırlar (Sheean, 2003: 122). Aynı nedenlerden dolayı Goodman, modern liberalizm ve Marksizm gibi alternatif radikal ideolojileri yerinden yönetim düşüncesi ve sosyal mühendislik konusundaki eğilimleri dolayısıyla reddetmektedir. Goodman için anarşizm, özgürlük ve toplumsal değişime yeterli düzeyde arka çıkabilecek tek ideolojik çerçeve olarak görülmektedir. Ona göre (2010: 143), “anarşizm ya da daha iyisi, anarko-pasifizm (toplumsal değişim hareketleri içerisinde örgütlü şiddete ve kurumlara karşı çıkan anarşist anlayış) günümüzün gelişmiş toplumlarının bürokrasilerini, karar verme konusunda aşırı merkezîleşmelerini ve sosyal mühendislik gibi problematik durumlarını ve tehlikelerini tutarlı bir şekilde öngörmüştür”. -/- Siyaset, sosyoloji ve felsefe gibi çeşitli alanlar içerisinde etkili olan anarşist kuramlar, radikal bir söylem olarak eğitimcileri ve araştırmacıları yeni öğretilere ve uygulamalara teşvik etme konusunda itici bir güç oluşturabilmektedirler. Anarşist yaklaşımlardan eğitim kuramı ve araştırmalara yönelik daha belirleyici bir rol alması beklenmektedir, ancak bu yaklaşımlar mevcut radikal akademik görüşü büyük ölçüde etkisi altına alan Marksizm’in eğitim alanında göstermiş olduğu aynı etkiyi gösterememiştir. Anarşist düşünceleri eğitim alanı içerisinde daha etkili ve görünür kılabilmek amacıyla Paul Goodman, Francisco Ferrer ve Alexander Neill’ın ileri sürmüş olduğu çeşitli düşünceler, girişimler ve uygulamalar ortaya çıkmıştır. Bu doğrultuda Goodman’ın anarşizme ilişkin düşünceleri ile bu çalışma sıkı bir anarşizm tahlili, eleştirisi ve felsefesinden öte anarşist anlayışın eğitimdeki uygulanabilirliğine yönelik bir soruşturma içerisine girmekte ve anarşist yaklaşımın mevcut eğitim sistemlerinden hangi yönleriyle farklılaştığını, sonucunda etkili bir eğitim anlayışı ortaya koyup koyamadığını tartışmaktadır. (shrink)

Öz: Frege özel adların (ve diğer dilsel simgelerin) anlamları ve gönderimleri arasında ünlü ayrımını yaptığı “Anlam ve Gönderim Üzerine” (1948) adlı makalesinde, bu ayrımın önemi, gerekliliği ve sonuçları üzerine uzun değerlendirmeler yapar ancak özel adın anlamından tam olarak ne anlaşılması gerektiğinden yalnızca bir dipnotta kısaca söz eder. Örneğin “Aristoteles” özel adının anlamının Platon’un öğrencisi ve Büyük İskender’in öğretmeni ya da Stagira’da doğan Büyük İskender’in öğretmeni olarak alınabileceğini söyler. Burada dikkat çeken nokta örnekteki özel adın olası anlamları olarak gösterilen belirli betimlemelerin (...) de özel ad içeriyor olması. Anlamın Frege için bileşimsel olduğu, bir başka deyişle bir dilsel simgenin anlamının (varsa) parçalarının anlamlarınca belirlendiği düşünülürse, örnekteki belirli betimlemelerin anlamlarının saptanabilmesi için içerdikleri özel adların da anlamları saptanıp betimleme içinde geçtikleri yere konmalıdır. Bu işlem hiçbir özel ad kalmayana kadar sürdürülmelidir. Ancak biraz düşünülünce bir özel adın nesnesini tekil olarak betimleyecek ve içinde özel ad geçmeyecek bir betimleme bulmanın kolay olmadığı görülür. Örneğin yukarıdaki betimlemelerde geçen “Platon”, “Büyük İskender” ve “Stagira” gibi özel adların anlamları olabilecek ancak özel ad içermeyen betimlemeler bulmak pek kolay görünmüyor. Ortaya bir sonsuz gerileme sorunu çıkmış gibi duruyor. Frege’nin anlam-gönderim ayrımını için ciddi sonuçları olabilecek bu sorunu Frege çözebilir mi? Bu yazıda bu sorunun yanıtını arayacağım. Sorunu betimledikten sonra Frege’nin önündeki seçenekleri (örneğin bağlama duyarlı terimlerden (gösterme adılları veya belirteçler) yararlanma veya bağlamı sınırlama gibi) değerlendireceğim. -/- Abstract: In his “Sense and Reference” (1948), Frege makes his famous distinction between the sense and the reference of a proper name (and other signs) and discusses at length the significance, necessity and consequences of the distinction, but he explains how the sense of a proper name should be understood very briefly in a footnote. According to him, for example, the sense of the proper name “Aristotle” can be taken as the pupil of Plato and teacher of Alexander the Great or the teacher of Alexander the Great who was born in Stagira. What is interesting here is that the definite descriptions given as the possible senses of this proper name do themselves contain proper names too. Since the sense is something compositional for Frege, which means the sense of a linguistic sign is determined by its constituents (if there are any), in order to determine the sense of definite descriptions in question, we should first determine the senses of proper names they contain and substitute these senses with the proper names themselves. This process should continue until no proper name remains. However, it does not seem easy to find a definite description which describes the object of a proper name uniquely but contains no proper name itself. For instance, could we find appropriate senses that contain no proper name for “Plato”, “Alexander the Great” and “Stagira”? It does not seem likely. A problem of infinite regress appears to arise. Can Frege solve this problem, which poses a serious threat for his sensereference distinction? I will explore this problem in this paper. After explaining the problem, I will discuss the options (e.g. turning to indexicals or context restriction) Frege can take to deal with it. (shrink)

This article aims to provide a theory of atonement, termed the "Agápēic Theory," which is formulated within a philosophical framework that has the aim of humans flourishing to the maximum level through partaking in an everlasting relationship of love with God. The Agápēic Theory will be formulated by using a certain conception of love, introduced by Alexander Pruss, into the field of applied ethics, and also various elements from other existing theories of the Atonement found within the fields of (...) analytic theology, in the work of Richard Swinburne, Eleonore Stump and Robin Collins, and systematic/biblical theology, in the work of Karl Barth and N.T Wright, which will both help to ground the Agápēic Theory on firm philosophical and theological grounds and ultimately provide a robust theory of the Atonement. (shrink)

Résumé Le débat holisme-réductionnisme se structure autour de trois domaines sémantiques : l 'ontologie, la méthodologie et l'épistémologie. Généralement, une méthodologie analytique s'accompagne d'une ontologie atomiste et de la réduction des lois et théorie des niveaux d'organisation supérieurs aux lois et théorie des niveaux inférieurs. Par contre, une ontologie holiste, relationnelle peut s'accorder au concept d'émergence. En conséquence dans l'élaboration des lois et théories d'un phénomène appartenant à un niveau donné la prise en compte du niveau d'organisation supérieurs se révélera (...) déterminante. Les propositions philosophiques anti-mécanicistes de précurseur tels que Bradley, S. Alexander, A.N. Whitehead, C.L. Morgan, D.C. Broad, même en restant au niveau d'une forme de proto-émergentisme représentent le fondement épistémologique à partir duquel s'est développée une méthodologie véritablement émergentiste. Abstract The holism-reductionism debate is structured around three areas of semantics: ontology, methodology and epistemology. As a general rule, an analytical methodology goes with an atomist ontology, and the reduction of laws and theories from the higher levels of organisation to the laws and theories of lower levels. On the other hand, a holistic and relational ontology can be in unison with the concept of emergence. As a consequence, in elaborating laws and theories of a phenornenon of a given level, taking into account that the higher level of organisation will be determinant. The philosophical and anti-mechanistic propositions of precursors such as F. Bradley, S. Alexander, A.N. Whitehead, C.L. Morgan, D.C. Broad, even remaining at the level of a kind of proto-emergentism represent the epistemological basis on which a true emergentist methodology has been developed. (shrink)

...If, in some places, backward science determines the remaining period by the lack of optimism only by the number 123456789, then our progressive science expands it to 987654321, which is eight times more advanced than theirs. However, due to the inherent caution of scientists, both sides do not specify the measuring unit of reference — year, day, hour or minute are meant. Leonid Leonov. Collected Op. in ten volumes. Volume ten. M.: IHL, 1984, p.583. -/- The modern men being as (...) a rule is proceeding in three relatively autonomous, but immanently coexisting, and each penetrating dialectically through other, and each contesting even cruelly with other, and each more or less dominating on other, differently in various societies, worlds: the first one of the barbarity, the second one the culture, the third one the civilization... Barbarity is the mode of coexistence of autonomous human societies based on the unlimited will to act so as subject wants to do without any limitations of his activities... Culture is the mode of coexistence of autonomous human societies based on the most ancient testaments, customs, traditions etc of the highestly sacrified appearence... Civilisation is the mode of coexistence of autonomous human societies based on the reasoned or legitimated by social contracts, by profits, by expediency and so more constitutions, institutions etc... -/- Andrei Melnikov-Pechersky in his epic "In the Woods" says that there was a movement among the Old Believers in Russia, or a current that proclaimed Kostroma the new and, it seems, the only true Jerusalem, in an apocalyptic sense, of course, which in its spiritual scale was probably not inferior to the Bogomils, shakers, Mormons, or else and the whole Reformation in potential. In Western Europe, every more or less convex nuance of the history of a state or region (even if it is a small San Marino) is overgrown with almost a dozen institutions, not always state ones, by the way, in which almost every sneeze and step of very ambivalent historical subjects in a broad sense is studied. Especially in the young, but very pretentious America of the United States, which embodies all world justice. In our country, for example, even many leading humanitarian specialists do not realize the spiritual value of the Ipatievsky MONASTERY. The Russian writer Boris Shiryaev, who died quite a long time ago and in a very far abroad, devoted a special part of his documentary and artistic epic of wanderings "The Inextinguishable Lampada" to an entertaining and instructive, tragic fate of a kind of village monarchy in some Villages of the Kostroma province (I could not identify the area, and, frankly, I did not really try) in the early years The Soviet government. At the same time, all Russians learn about the French emperor Napoleon almost with their mother's milk how many percent of cyanide potassium was found in his hair, they reflect on Lermontov's "Airship" (probably, just not to "memorize" the imposed "Borodino" by heart). The events, of course, are incomparable, but the fact is significant. The outstanding national artist (if not to say a thinker of the Chesnyakov level) Grigory Pavlovich Kusochkin was glorified wherever, in whatever catalogues he was not included. Paris, London, New York, St. Petersburg, Moscow... To look at some smear of luminaries like Picasso or Modigliani, international tourist routes are organized in the restaurant toilet using the finest marketing technologies, and we did not even know Grigory Pavlovich by sight until, thank God, a series of TV shows on all Russian channels was dedicated to him in one gulp. Why is this happening? Is it a consequence of poverty or the result of the conscious policy of the ruling elite of the country and the world? The regions of the Kostroma Region are Austria, Switzerland, Bavaria, Armenia, Moldova, and Georgia... Georgia! I served in the army there. In this small but very great country, judging even by the appearance of its President Shevardnadze, although it is smaller than the Kostroma region, there are so many different, but Georgian-speaking peoples! Kakhetians, Meskhetians, Imereti, Iveretians, Mingrelians, Khevsurs... Adjarians (mostly Georgian-speaking Muslims) even have their own autonomy. And some peoples are not Georgian—speaking at all — South Ossetians, Abkhazians, Kurds, Armenians, Greeks, even Assyrians. In the Kostroma Region, and in any Russian "province" — not much less: there are plenty of the same Georgians or Armenians everywhere, quite moderate, loyal, and so on. Having, as a rule, their own officially registered associations within the framework of cultural autonomy. Well done! And Israel! He is the only one with all his "illegal" (and I am for the fact that every nation knows better where its ancestral lands are) territories half the size of the Kostroma region. The total number of Jews worldwide, according to the "Soviet Encyclopedic Dictionary" in 1987, is about 14 million. Meanwhile, the fate of Israel is being preoccupied (it is very instructive how he achieved this!) all the united nations of the world. In the Kostroma Region and its diaspora, it seems to everyone, and especially to its semi-migrant, Varangian leadership. I don't care if they build a public atomic bomb here in the form of a nuclear power plant or not. Because they do not know the value of this land, the greatness of its spirit. Kostroma is a holy land. I will immediately make a reservation that by Kostroma I mean not only the modern region, but the entire area that has ever historically been associated with Kostroma. The USSR is also a part of the great historical Russia. In this sense, even the entire era of the Russian Romanov Empire is the Kostroma region. Or: many toponymic objects of our native land are called mysteriously beautiful: Sharya, Shunga, Shekshema, Sholezhka, - we need to find out what kind of peoples — and where are they now? — we left such euphonious archetypal combinations, because these are our Kostromsky peoples, these are our Kostroma people. Or, say, the classic of American and world sociology Pitirim Alexandrovich Sorokin writes in his autobiographical scientific novel "The Long Way" that he studied at the Khrenovskaya (what a strong word!) teachers' seminary of Kostroma province, but in an administrative row for propaganda activities, gendarmes were taken by sledge to the prison of the city of Kineshma - is this not a fact for Kostroma, and primarily for him, local history, although Kineshma has long been attributed to the Ivanovo region, and Pitirim Alexandrovich is buried on the other side of the planet?! I have not the slightest doubt that Kostroma provided spiritual food, gave birth to and nurtured a huge intellectual diaspora with extremely valuable material on a national, global scale. And this is both in direct and indirect order, in the form of a chain reaction. Apparently, it is easy for an intelligent person to grow up in Kostroma, but it is impossible to live, and somewhere on the contrary. Therefore, it is not surprising that the geneticist academician D. K. Belyaev, who was born in the village of Protasov near Nerekhta, very close to Kostroma, glorified Moscow and Siberia with his discoveries and practical results, which immeasurably enriched the Soviet state treasury with foreign exchange income from the sale of the most valuable fur grown according to the biotechnology developed by him in a much shorter time than it usually turns out in nature. And in Kostroma, most likely, few people know who he is and what he is famous for. I will focus in more detail on one of the aspects of his great life. This happened back in the so-called pre-Perestroika times. In a series of his speeches, Dmitry Konstantinovich, based on the results of his and colleagues' research, emphasized, in his opinion, the determining role of the biological factor in shaping the content of human essence, of course, only in a philosophical, conceptual aspect. For some reason, this was opposed by a geneticist, as they say, persecuted at one time by the "senile" in selectionism (including human nature) by the Michurino-Lysenkoists, academician N. P. Dubinin, which personally remains incomprehensible to me until now. With a grateful curtsey to Academician Dubinin and his point of view, the famous French humanist, member of the Politburo of the French Communist Party Lucien Sav appeared on the pages of the Communist magazine. The material was clearly titled: "Problems are not only scientific, but also political." He very indecently attributed the views of academician Belyaev to "a reactionary ideology that tries to put genetics at its service, and more broadly, biology, in order to present all kinds of social inequalities of all kinds as inherent in nature itself"(1). I would like to see any ideology that does not try to "put this or that at its service," much less something worthwhile... A little later, the editorial of the Communist hit the "biologizers", and soon Dmitry Konstantinovich was gone. In short, it is only on the example of our fellow countrymen that you can write interesting, world-class essays on science and its history, but instead our scientists should fit their global potencies into a page and a half (good yet. if not entirely at their own expense), and then for at least three years to guess whether they will be published or not. Now it no longer surprises me how at one time, when, after reading the listener card I filled out, the sweetest girl from the IPKPON office at USU congratulated me for something. It turned out that the dean of the Faculty of Philosophy of USU, doctor, professor, Honored Scientist, and now academician Konstantin Niko-laevich Lyubutin is a countryman, Kostromsky, or rather Manturovsky by origin, as I write below in the notes — we are Kostromendors. To him, my fellow citizen in the most subtle micropatriotic dimensions, I owe a lot in my professional and social development, even in survival. Because that's how it often turns out: you can be born here, sometimes you can live here... It's very hard. Maybe the Kostroma origin of an outstanding Russian historian of philosophy, organizer of science and education, educator and friend of a galaxy of people devoted to the Motherland and the cause is not a great milestone in the history of the region, but name me at least a dozen Russian cities on the scale of Kostroma, from where such intellectual ones would come out into the world and light luminaries like ours. No matter who you take from the world significance of the pillars of national (and world, and foreign, - even the great Rabbi of Lubavitcher spent three years in exile in a Campfire, — I learned from some foreign voices) history, literature, culture in general, technology, science and so on - you will always find someone, which is very directly related to Kostroma. Pushkin, Lermontov, Gorky. Alexander Nikolaevich Ostrovsky, Pisarev, Uspensky, Katenin, Florensky, Savrasov, Kustodiev, Dyagilev, Mikhalkov, Alexander Alexandrovich Zinoviev; writers, artists, entrepreneurs, revolutionaries, inventors, politicians... In some world-famous for its classic Russian provincialism, Kologriv has been storing, figuratively speaking, unique sketches, if not of Leo-Nardo da Vinci himself, then certainly of his school, almost since the seventeenth century. And not only that. Nevertheless, the well-known Chukhloma to the Fatherland, in addition to thinkers of the rank of Rozanov and Zinoviev (where should domestic philosophers mature and not be born, if not in Chukhloma, Manturov or Khrenknowswhere?), gave an actor of amazing, national, originality — Mikhail Pugovkin, who can not be confused with anyone, a role that no one will repeat. (shrink)

Wall, G. Locke's attack on innate knowledge.--Harris, J. Leibniz and Locke on innate ideas.--Greenlee, D. Locke's idea of idea.--Aspelin, G. Idea and perception in Locke's essay.--Greenlee, D. Idea and object in the essay.--Mathews, H. E. Locke, Malebranche and the representative theory.--Alexander, P. Boyle and Locke on primary and secondary qualities.--Ayers, M. R. The ideas of power and substance in Locke's philosophy.--Allison, H. E. Locke's theory of personal identity.--Kretzmann, N. The main thesis of Locke's semantic theory.--Woozley, A. D. Some remarks (...) on Locke's account of knowledge.--Laudan, L. The nature and sources of Locke's views on hypotheses. (shrink)

The paper discusses the sense in which the changes undergone by normative economics in the twentieth century can be said to be progressive. A simple criterion is proposed to decide whether a sequence of normative theories is progressive. This criterion is put to use on the historical transition from the new welfare economics to social choice theory. The paper reconstructs this classic case, and eventually concludes that the latter theory was progressive compared with the former. It also briefly comments on (...) the recent developments in normative economics and their connection with the previous two stages. (Published Online April 18 2006) Footnotes1 This paper suspersedes an earlier one entitled “Is There Progress in Normative Economics?” (Mongin 2002). I thank the organizers of the Fourth ESHET Conference (Graz 2000) for the opportunity they gave me to lecture on this topic. Thanks are also due to J. Alexander, K. Arrow, A. Bird, R. Bradley, M. Dascal, W. Gaertner, N. Gravel, D. Hausman, B. Hill, C. Howson, N. McClennen, A. Trannoy, J. Weymark, J. Worrall, two annonymous referees of this journal, and especially the editor M. Fleurbaey, for helpful comments. The editor's suggestions contributed to determine the final orientation of the paper. The author is grateful to the LSE and the Lachmann Foundation for their support at the time when he was writing the initial version. (shrink)

1.Summary The key terms. 1. Key term: ‘Sunyata’. Nagarjuna is known in the history of Buddhism mainly by his keyword ‘sunyata’. This word is translated into English by the word ‘emptiness’. The translation and the traditional interpretations create the impression that Nagarjuna declares the objects as empty or illusionary or not real or not existing. What is the assertion and concrete statement made by this interpretation? That nothing can be found, that there is nothing, that nothing exists? Was Nagarjuna denying (...) the external world? Did he wish to refute that which evidently is? Did he want to call into question the world in which we live? Did he wish to deny the presence of things that somehow arise? My first point is the refutation of this traditional translation and interpretation. 2. Key terms: ‘Dependence’ or ‘relational view’. My second point consists in a transcription of the keyword of ‘sunyata’ by the word ‘dependence’. This is something that Nagarjuna himself has done. Now Nagarjuna’s central view can be named ‘dependence of things’. Nagarjuna is not looking for a material or immaterial object which can be declared as a fundamental reality of this world. His fundamental reality is not an object. It is a relation between objects. This is a relational view of reality. This is the heart of Nagarjuna’s ideas. In the 19th century a more or less unknown Italian philosopher, Vincenzo Goberti, spoke about relations as the mean and as bonds between things. Later, in quantum physics and in the philosophy of Alfred North Whitehead we are talking about interactions and entanglements. These ideas of relatedness or connections or entanglements in Eastern and Western modes of thought are the main idea of this essay. Not all entanglements are known. Just two examples: the nature of quantum entanglements is not known. Quantum entanglements should be faster than light. That's why Albert Einstein had some doubts. A second example: the completely unknown connections between the mind and the brain. Other examples are mysterious like the connections between birds in a flock. Some are a little known like gravitational forces. 3. Key terms: ‘Arm in arm’. But Nagarjuna did not stop there. He was not content to repeat this discovery of relational reality. He went on one step further indicating that what is happening between two things. He gave indications to the space between two things. He realized that not the behaviour of bodies, but the behaviour of something between them may be essential for understanding the reality. This open space is not at all empty. It is full of energy. The open space is the middle between things. Things are going arm in arm. The middle might be considered as a force that bounds men to the world and it might be seen as well as a force of liberation. It might be seen as a bondage to the infinite space. 4. Key term: Philosophy. Nagarjuna, we are told, was a Buddhist philosopher. This statement is not wrong when we take the notion ‘philosophy’ in a deep sense as a love to wisdom, not as wisdom itself. Philosophy is a way to wisdom. Where this way has an end wisdom begins and philosophy is no more necessary. A.N. Whitehead gives philosophy the commission of descriptive generalization. We do not need necessarily a philosophical building of universal dimensions. Some steps of descriptive generalization might be enough in order to see and understand reality. There is another criterion of Nagarjuna’s philosophy. Not his keywords ‘sunyata’ and ‘pratityasamutpada’ but his 25 philosophical examples are the heart of his philosophy. His examples are images. They do not speak to rational and conceptual understanding. They speak to our eyes. Images, metaphors, allegories or symbolic examples have a freshness which rational ideas do not possess. Buddhist dharma and philosophy is a philosophy of allegories. This kind of philosophy is not completely new and unknown to European philosophy. Since Plato’s allegory of the cave it is already a little known. (Plato 424 – 348 Befor Current Era) The German philosopher Hans Blumenberg has underlined the importance of metaphors in European philosophy. 5. Key terms: Quantum Physics. Why quantum physics? European modes of thought had no idea of the space between two this. They were bound to the ideas of substance or subject, two main metaphysical traditions of European philosophical history, two main principles. These substances and these subjects are two immaterial bodies which were considered by traditional European metaphysics as lying, as a sort of core, inside the objects or underlying the empirical reality of our world. The first European scientist who saw with his inner eye the forces between two things had been Michael Faraday (1791-1867). Faraday was an English scientist who contributed to the fields of electromagnetism. Later physicists like Albert Einstein, Niels Bohr, Erwin Schrödinger, Werner Heisenberg and others followed his view in modern physics. This is a fifth point of my work. I compare Nagarjuna with European scientific modes of thought for a better understanding of Asia. I do not compare Nagarjuna with European philosophers like Hegel, Heidegger, Wittgenstein. The principles and metaphysical foundations of physical sciences are more representative for European modes of thought than the ideas of Hegel, Heidegger and Wittgenstein and they are more precise. And slowly we are beginning to understand these principles. Let me take as an example the interpretation of quantum entanglement by the British mathematician Roger Penrose. Penrose discusses in the year of 2000 the experiences of quantum entanglement where light is separated over a distance of 100 kilometers and still remains connected in an unknown way. These are well known experiments in the last 30 years. Very strange for European modes of thought. The light should be either separated or connected. That is the expectation most European modes of thought tell us. Aristotle had been the first. Aristotle (384 - 322 Before Current Era) was a Greek philosopher, a student of Plato and a teacher of Alexander the Great. He told us the following principle as a metaphysical foundation: Either a situation exists or not. There is not a third possibility. Now listen to Roger Penrose: “Quantum entanglement is a very strange type of thing. It is somewhere between objects being separate and being in communication with each other” (Roger Penrose, The Large, the Small and the Human Mind, Cambridge University Press. 2000 page 66). This sentence of Roger Penrose is a first step of a philosophical generalization in a Whiteheadian sense. 6. Key terms: ‘The metaphysical foundations of modern science’ had been examined particularly by three European and American philosophers: E. A. Burtt, A.N. Whitehead and Hans-Georg Gadamer, by Gadamer eminently in his late writings on Heraclitus and Parmenides. I try to follow the approaches of these philosophers of relational views and of anti-substantialism. By ‘metaphysical foundations’ Edwin Arthur Burtt does not understand transcendental ideas but simply the principles that are underlying sciences. -/- 7. Key terms: ‘Complementarity’, ‘interactions’, ‘entanglements’. Since 1927 quantum physics has three key terms which give an indication to the fundamental physical reality: Complementarity, interactions and entanglement. These three notions are akin to Nagarjuna’s relational view of reality. They are akin and they are very precise, so that Buddhism might learn something from these descriptions and quantum physicists might learn from Nagarjuna’s examples and views of reality. They might learn to do a first step in a philosophical generalisation of quantum physical experiments. All of us we might learn how objects are entangled or going arm in arm. [The end of the summary.] -/- « Wenn du gerade das, wodurch auch immer du gefesselt bist, erkennst, wirst du zur Freiheit gelangen. Wenn du diesen speziellen Pfad verwirklichst, gelangst du in einem Leben zur Buddhaschaft. Deswegen verhält es sich folgendermaßen : Wenn plötzlich die Geistesregung « Begierde » enststeht, dann betrachte, ohne ihr zu folgen, direkt ihre Essenz und verweile in dieser Betrachtung, ohne Ablenkungen zuzulassen. Auf diese Weise reinigt Begierde sich selbst, ohne aufgegeben zu werden, da sie ohne Grundlage und Ursprung entsteht. Das wird « Befreiung in sich selbst », « unterscheidende ursprüngliche Weisheit » oder Buddha Amitabha » genannt ». Jigden Sumgön, Licht, das die Dunkelheit durchbricht, Otter Verlag, München 2006, Seite 47, 48 . (shrink)

L'écologie préénergétique des années 1905-1935 est à la recherche de ses objets d'étude. Des unités fondamentales de la nature (telles que formation végétale, association végétale, climax, biome, communauté biotique, écosystème) se trouvent en compétition et se succèdent les unes aux autres. Autour des années 1920 et 1930, la philosophie organiciste d'Alfred N. Whitehead, ainsi que la perspective évolutionniste d'Herbert Spencer et les propositions émergentistes de Samuel Alexander et Conwy L. Morgan, deviennent des références sous-jacentes au débat épistémologique concernant les (...) unités de base de l'écologie. Des auteurs comme Frederic E. Clements et John Phillips soutiendront plusieurs formes d'organicisme écologique, tandis que Henry A. Gleason interprétera l'association végétale comme le résultat d'une juxtaposition fortuite d'individus. Enfin, et paradoxalement, l'écosystème de Arthur G. Tansley, tout en faisant partie, à l'origine, d'une perspective anti-organiciste, deviendra l'unité fondamentale de programmes de recherche qui se voudront, au moins dans leurs intentions, émergentistes. (shrink)

This seventh volume of Collected Papers includes 70 papers comprising 974 pages on (theoretic and applied) neutrosophics, written between 2013-2021 by the author alone or in collaboration with the following 122 co-authors from 22 countries: Mohamed Abdel-Basset, Abdel-Nasser Hussian, C. Alexander, Mumtaz Ali, Yaman Akbulut, Amir Abdullah, Amira S. Ashour, Assia Bakali, Kousik Bhattacharya, Kainat Bibi, R. N. Boyd, Ümit Budak, Lulu Cai, Cenap Özel, Chang Su Kim, Victor Christianto, Chunlai Du, Chunxin Bo, Rituparna Chutia, Cu Nguyen Giap, Dao (...) The Son, Vinayak Devvrat, Arindam Dey, Partha Pratim Dey, Fahad Alsharari, Feng Yongfei, S. Ganesan, Shivam Ghildiyal, Bibhas C. Giri, Masooma Raza Hashmi, Ahmed Refaat Hawas, Hoang Viet Long, Le Hoang Son, Hongbo Wang, Hongnian Yu, Mihaiela Iliescu, Saeid Jafari, Temitope Gbolahan Jaiyeola, Naeem Jan, R. Jeevitha, Jun Ye, Anup Khan, Madad Khan, Salma Khan, Ilanthenral Kandasamy, W.B. Vasantha Kandasamy, Darjan Karabašević, Kifayat Ullah, Kishore Kumar P.K., Sujit Kumar De, Prasun Kumar Nayak, Malayalan Lathamaheswari, Luong Thi Hong Lan, Anam Luqman, Luu Quoc Dat, Tahir Mahmood, Hafsa M. Malik, Nivetha Martin, Mai Mohamed, Parimala Mani, Mingcong Deng, Mohammed A. Al Shumrani, Mohammad Hamidi, Mohamed Talea, Kalyan Mondal, Muhammad Akram, Muhammad Gulistan, Farshid Mofidnakhaei, Muhammad Shoaib, Muhammad Riaz, Karthika Muthusamy, Nabeela Ishfaq, Deivanayagampillai Nagarajan, Sumera Naz, Nguyen Dinh Hoa, Nguyen Tho Thong, Nguyen Xuan Thao, Noor ul Amin, Dragan Pamučar, Gabrijela Popović, S. Krishna Prabha, Surapati Pramanik, Priya R, Qiaoyan Li, Yaser Saber, Said Broumi, Saima Anis, Saleem Abdullah, Ganeshsree Selvachandran, Abdulkadir Sengür, Seyed Ahmad Edalatpanah, Shahbaz Ali, Shahzaib Ashraf, Shouzhen Zeng, Shio Gai Quek, Shuangwu Zhu, Shumaiza, Sidra Sayed, Sohail Iqbal, Songtao Shao, Sundas Shahzadi, Dragiša Stanujkić, Željko Stević, Udhayakumar Ramalingam, Zunaira Rashid, Hossein Rashmanlou, Rajkumar Verma, Luige Vlădăreanu, Victor Vlădăreanu, Desmond Jun Yi Tey, Selçuk Topal, Naveed Yaqoob, Yanhui Guo, Yee Fei Gan, Yingcang Ma, Young Bae Jun, Yuping Lai, Hafiz Abdul Wahab, Wei Yang, Xiaohong Zhang, Edmundas Kazimieras Zavadskas, Lemnaouar Zedam. (shrink)

REPRODUÇÃO EM NOVILHAS LEITEIRAS -/- INTRODUÇÃO -/- O principal objetivo da criação de substitutos em gado leiteiro é produzir uma novilha que tenha seu parto aos dois anos de idade (23 a 25 meses) e com um peso de 550 a 580 kg. O manejo reprodutivo das novilhas começa quando estas atingem 14 ou 15 meses de idade e um peso de 350 a 370 kg. A produção de novilhas deve ser suficiente para substituir as vacas descartadas anualmente (25 a (...) 35%), e para contribuir com o crescimento do rebanho. Espera-se que em um gado leiteiro deva haver uma população de animais de reposição, desde um dia de vida até à fase de novilha ao parto, correspondendo pelo menos a 70 % do total das vacas (figura 1). -/- Figura 1: A meta do programa de produção de substitutos ou fêmeas de reposição consiste em uma novilha que chegue ao seu primeiro parto aos 24 ou 25 meses de idade, entre um peso de 550 a 580 kg. Elaborado pelo autor. -/- A produção de novilhas depende basicamente de três fatores: da fertilidade das vacas, ou seja, do número de bezerras nascidas anualmente; da mortalidade durante a criação e desenvolvimento; e da eficiência reprodutiva das novilhas. O manejo reprodutivo moderno das novilhas é orientado para a utilização da inseminação artificial, seja em um estro natural ou sincronizado. As novilhas representam a população animal geneticamente mais avançada no rebanho, portanto, o mérito genético de suas crias obtidas por inseminação é maior do que o das crias das vacas adultas. Além disso, as crias das novilhas obtidas mediante a inseminação aceleram o avanço genético, uma vez que contribuem com uma proporção maior de substituições do rebanho em comparação com as crias das vacas de outras faixas etárias. Além disso, as novilhas são as fêmeas mais férteis do rebanho (porcentagem de concepção: 60 a 70% vs 30 a 40% em vacas), pelo que o custo do sêmen por gestação é menor em comparação com as vacas adultas, o que permite investir em melhores touros e em sêmen sexado. -/- 1. PUBERDADE -/- A puberdade é definida como a fase de desenvolvimento em que a fêmea apresenta o seu primeiro estro fértil. Regularmente as novilhas leiteiras, sob condições ótimas de manejo, chegam à puberdade entre 11 e 12 meses de idade, ou seja, antes de alavancar o peso recomendado para receber o primeiro serviço. Vale salientar que as novilhas podem ficar gestantes após a puberdade; no entanto, isto não é conveniente porque ainda não completou-se o seu desenvolvimento. Se ficarem gestantes nos primeiros ciclos estrais, as novilhas poderiam chegar ao parto com pouco desenvolvimento físico, o que provocaria distocias e baixa produção de leite (figura 2). A ativação do sistema neuroendócrino para que a bezerra atinja a puberdade é regulada principalmente pelo estado nutricional (condição corporal). A transição do anestro pré-puberal à ciclicidade puberal coincide com um aumento da condição corporal e das concentrações de insulina, IGF-I e leptina. Estes hormônios agem como sinais metabólicos no hipotálamo e hipófise que modificam a frequência de secreção das gonadotropinas, resultando na maturação folicular e ovulação. O atraso em relação à puberdade está diretamente relacionado com deficiências na alimentação; esta condição verifica-se em criações pouco tecnificadas, principalmente de pequenos e médios produtores. As novilhas que já atingiram o peso para receber o primeiro serviço e não apresentaram estro, devem ser examinadas por via retal para excluir possíveis anormalidades do desenvolvimento, tais como freemartinismo ou hipoplasia genital. -/- Figura 2: O fator mais importante que determina a puberdade é a nutrição. Bezerras bem alimentadas apresentam ciclos estrais aos 11 meses de idade e devem ser inseminadas aos 14 ou 15 meses de idade, com um peso de 350 a 370 kg. Acervo pessoal do autor. -/- 2. DETECÇÃO DE ESTRO E INSEMINAÇÃO ARTIFICIAL -/- A baixa eficiência na detecção de estros é o problema que mais afeta a eficiência reprodutiva das novilhas. De acordo com a duração do estro (8 a 18 horas), a observação das novilhas em períodos de 30 minutos durante a manhã e à tarde, permite detectar em estro até 70% das fêmeas, enquanto a observação contínua (24 horas) aumenta a eficiência na detecção até 95% (figuras 3 e 4). No manejo tradicional dos rebanhos leiteiros, as novilhas recebem pouca atenção por parte dos trabalhadores, o que resulta em baixa eficiência na detecção de estros (50 a 60%). Em diferença das vacas adultas em lactação, as novilhas estão menos expostas a fatores que diminuem a expressão do estro, portanto, com uma rotina de observação, de pelo menos duas horas na manhã (6h a 8h da manhã) e duas horas pela tarde até a noite (17h da tarde a 19h da noite), pode-se detectar até 90% das fêmeas no estro (figura 5). -/- Figura 3: O fator que mais influencia a idade ao primeiro parto é a baixa eficiência na detecção de estros, pelo que é recomendável a observação de estros com pessoal qualificado, em períodos de pelo menos duas horas pela manhã e duas à tarde. Acervo pessoal do autor. -/- Figura 4: Com a observação contínua é possível alcançar de 90 a 95% de eficiência na detecção de estros. Acervo pessoal do autor. -/- Figura 5: A inseminação deve ser realizada durante o período de receptividade sexual. Com boa eficiência na detecção de estros, a inseminação pode ser praticada no programa AM-PM e PM-AM, ou em apenas um turno de inseminação pela manhã (10:00), com bons resultados. -/- 3. TAXA DE PRENHEZ -/- O melhor indicador de eficiência reprodutiva é a taxa de prenhez. Este indicador refere-se à proporção de animais gestantes do total elegível para inseminação, num período equivalente a um ciclo estral. Como já se descreveu no trabalho Fisiologia do Estro e do Serviço na Reprodução Bovina, este indicador considera a eficiência na detecção de estros e a porcentagem de concepção, e reflete com maior objetividade a eficácia do manejo reprodutivo. Este parâmetro pode ser melhorado através de um aumento da proporção de novilhas detectadas em estro, o que se obtém aumentando o tempo de observação e aplicando técnicas de sincronização do estro (figura 6). -/- 4. INSEMINAÇÃO DE NOVILHAS COM SÊMEN SEXADO -/- A utilização de sêmen sexado é uma boa opção para a produção de novilhas de reposição. Com a nova tecnologia disponível para a separação de espermatozoides com o cromossomo x, é possível alcançar até 90% de crias fêmeas; no entanto, o processo de separação de espermatozoides tem baixa eficiência, o que limita o número de espermatozoides por palheta. As palhetas de inseminação com sêmen sexado contém de dois a três milhões de espermatozoides (doses de sêmen não sexado têm de 20 a 30 milhões). De acordo com os dados de fertilidade de gados comerciais, as novilhas inseminadas com sêmen sexado mostram de 10 a 20% menor concepção que novilhas inseminadas com sêmen não sexado, o que desencoraja o seu uso. Causas de baixa fertilidade não são conhecidas, no entanto, estão associadas com a menor concentração espermática e com alguns danos nos espermatozoides provocados pelo processo de separação. No entanto, o uso de sêmen sexado é uma opção viável para aumentar a produção de novilhas no rebanho, e com o melhoramento dos processos de separação espermática em pouco tempo se converterá em uma prática de rotina nos estábulos (figura 7). -/- Figura 6: Uma técnica que aumenta a eficiência na detecção dos estros consiste em pintar a região da grupa. Quando esta pintura desaparece ou se nota que as novilhas estão "talhadas", devem ser apalpadas via retal para determinar se existem sinais genitais de estro. Acervo pessoal do autor. -/- Figura 7: As novilhas são as fêmeas mais férteis do rebanho, por isso o custo do sêmen por gestação é menor em comparação com as vacas adultas, o que permite investir em melhores touros e em sêmen sexado. Acervo pessoal do autor. 5. MONTA DIRIGIDA -/- A monta dirigida ou direta é uma opção prática e eficaz para emprenhar as novilhas. Neste sistema se introduz um touro com um grupo de novilhas, para que ele se encarregue de encontrar as fêmeas em estro e proceder a monta. Em rebanhos comerciais, o ideal é a utilização de um touro para 25 fêmeas. No entanto, com este manejo perde-se a oportunidade de utilizar a inseminação artificial e, com isso, a possibilidade de melhoria genética. -/- 6. PROGRAMAS DE SINCRONIZAÇÃO DE ESTROS -/- Os tratamentos para sincronizar o estro das novilhas possuem os mesmos fundamentos que os utilizados nas vacas. -/- 6.1 Prostaglandina F2a -/- A PGF2α é utilizada para a sincronização de estros em grupos de novilhas, e também é utilizada para a indução do estro individualmente, nas fêmeas que são examinadas por via retal e têm um corpo lúteo. A resposta dos animais tratados é variável; em novilhas pode-se alcançar até 95% de animais em estro. O tempo de manifestação do estro após a injeção é de 48 a 120 horas. -/- 6.1.1 Dupla injeção de PGF2a -/- Além da sincronização dos animais selecionados pela presença de um corpo lúteo diagnosticado por palpação retal, existem dois programas que não incluem a palpação retal. Por exemplo, na segunda-feira, ou no dia preferido, injeta-se PGF2α em todas as novilhas que se deseja inseminar. Cerca de 50% das novilhas manifestarão estro nas próximas 48 a 120 horas. As fêmeas que não mostrarem estro receberão uma segunda injeção na segunda-feira seguinte (intervalo de sete dias). As que apresentaram estro com a primeira injeção teriam um corpo lúteo nesse momento, enquanto as que não o manifestaram estavam em estro ou em metaestro; assim, ao repetir o tratamento sete dias depois, estas últimas novilhas teriam um corpo lúteo e responderiam à PGF2α (figura 8). No outro programa, é administrada duas doses de PGF2α com 11 dias de separação/intervalo. As novilhas podem ser inseminadas no estro observado, após qualquer uma das duas injeções. Este programa oferece uma boa sincroniza- ção após a segunda injeção e é o programa de escolha na sincronização das novilhas receptoras de embriões (figura 9). -/- Figura 8: Sincronização do estro com dupla injeção de PGF2a com 7 dias de diferença/intervalo. Elaborado pelo autor. -/- Figura 9: Sincronização do estro com dupla injeção de PGF2a com 11 dias de diferença/intervalo. Elaborado pelo autor. -/- 6.2 Progestágenos -/- Existe um tratamento que consiste na inserção, na parte externa da orelha, de um implante que contém norgestomet, que permanece na região auricular por nove dias. Além disso, o tratamento é complementado com a injeção intramuscular de valerato de estradiol e norgestomet, no momento da colocação do implante. O tempo de apresentação do estro a partir da remoção do implante é de 48 a 72 horas e a proporção de animais em estro muitas vezes se torna maior do que 80%. Outro tratamento é baseado na inserção intravaginal de dispositivos de liberação de progesterona. O dispositivo pode ser utilizado durante 12 dias ou o período de exposição pode ser encurtado, desde que seja acompanhado da injeção de uma dose luteolítica de PGF2α, um dia antes ou no momento da remoção do dispositivo. A fertilidade global conseguida após o serviço no estro sincronizado é similar à obtida no estro natural; porém, algumas novilhas são menos férteis, o que está associado com alterações no desenvolvimento folicular e alterações na relação temporal entre o estro e a ovulação. Observou-se que o tratamento com implantes de norgestomet combinados com a injeção de valerato de estradiol pode induzir comportamento estral em animais que não estão ciclando normalmente. Isso ocorre porque os níveis de estradiol, administrados no primeiro dia, persistem até o momento da remoção do implante. Assim, ao remover a fonte do progestágeno e ao haver concentrações altas de estradiol se desencadeia o estro, o qual em novilhas anéstricas não é acompanhado de ovulação, enquanto que em novilhas ciclando se altera a relação temporal entre o estro, pico pré-ovulatório de LH e ovulação. Bons resultados são alcançados quando o valerato de estradiol não é administrado e é substituído por uma injeção de PGF2α no momento da remoção do implante. Outro fator que tem sido associado com baixa fertilidade é o dia do ciclo em que o tratamento começa. Observou-se que quando coincide com a presença de um corpo lúteo (diestro), a porcentagem de concepção é maior do que quando não há um corpo lúteo (proestro). Isto ocorre porque a concentração sérica do progestágeno, por si só, não é capaz de suprimir a secreção pulsátil de LH, o que faz com que o folículo dominante presente no momento de iniciar o tratamento não sofra atresia e persista até o dia da retirada do progestágeno, convertendo-se no folículo ovulatório. Com isso, o folículo já envelheceu e o ovócito já sofreu alterações que reduzem o seu potencial para desenvolver um embrião viável. Quando o tratamento coincide com a presença de um corpo lúteo, a secreção de LH é efetivamente suprimida devido ao efeito aditivo da progesterona secretada pelo corpo lúteo e do progestágeno exógeno, inserido na vaca, o que provoca a reposição folicular. Em condições de campo, a seleção das vacas pela presença de um corpo lúteo antes de iniciar o tratamento com progestágenos é impraticável, uma vez que não é possível visualizá-lo, além disso essa prática/seleção não faria sentido, já que seria mais fácil tratar estes animais com dose ou doses de PGF2α. Atualmente existem tratamentos para eliminar folículos dominantes e promover uma nova onda folicular. -/- 6.3 Progestágenos orais -/- O acetato de melengestrol (MGA) é um progestágeno administrado por via oral. Em fêmeas bovinas é utilizado para melhorar a eficiência alimentar nos currais de engorda, o que se consegue através da inibição da apresentação do estro. Como todos os progestágenos, o MGA inibe a secreção de LH, eliminando assim a maturação do folículo e a ovulação. Após a remoção do MGA, o folículo dominante termina o seu desenvolvimento e as fêmeas apresentam estro em forma sincronizada. A dose de MGA por novilha é de 0,5 a 1 mg por dia, em tratamentos que variam de 9 a 14 dias. A apresentação comercial de MGA contém 0,22 mg do hormônio por 1 g do produto. O MGA pode ser facilmente misturado com qualquer concentrado ou grão moído. Após o último dia de tratamento, o estro se apresenta de dois a seis dias. O intervalo de remoção do MGA ao estro é mais longo quando comparado com outros progestágenos. Isto deve-se ao tempo de remoção do MGA, uma vez que enquanto um implante ou dispositivo intravaginal é removido abruptamente, o MGA pode continuar a ser absorvido enquanto é removido do trato gastrointestinal. Com tratamentos de 14 dias podem-se obter porcentagens de concepção menores em comparação com o estro natural, o que se deve em grande parte à ovulação de folículos persistentes. Um tratamento eficaz, que também melhora a fertilidade, consiste na administração de MGA durante 14 dias, seguido de uma injeção de PGF2α 15 ou 17 dias após a remoção do progestágeno. Com este programa, uma alta proporção de fêmeas teriam um corpo lúteo no momento da injeção da PGF2α e apresentariam estro com boa sincronização. Outro tratamento eficaz consiste na administração do MGA durante nove dias, mais uma dose de PGF2α ao nono dia; com este programa também se obtêm bons resultados em sincronização do estro e fertilidade. Este tratamento foi avaliado com novilhas holandesas e a porcentagem de fêmeas sincronizadas é elevada (95%). A porcentagem de concepção é semelhante à obtida no estro natural. Estes resultados são comparáveis aos obtidos com outros programas, como implantes de norgestomet ou dispositivos intravaginais de liberação de progesterona, mas com um custo significativamente menor (figura 10). -/- 6.4 Sincronização da ovulação e inseminação em tempo fixo -/- Em contraste com o observado em vacas em lactação, a resposta das novilhas aos programas de sincronização da ovulação e inseminação a tempo fixo é deficiente, o que se reflete em porcentagens de concepção de 20 a 35% menores que as novilhas inseminadas no estro natural. A causa desta resposta está relacionada com diferenças no desenvolvimento folicular; assim, nas novilhas o tempo de desenvolvimento do folículo dominante é mais rápido e o tempo de domínio é mais curto do que nas vacas em lactação. Desta forma, o folículo da onda folicular sincronizada com a injeção de GnRH sofre atresia antes da injeção de PGF2α, de tal forma que quando se induz a ovulação com a segunda injeção de GnRH, as novilhas têm folículos em diferentes estádios de desenvolvimento, o que provoca assincronia entre a ovulação e a inseminação artificial. -/- Figura 10: Programa de sincronização do estro com Acetato de Melengestrol (MGA). Elaborado pelo autor. -/- 7. MANEJO DO ANESTRO -/- Uma vez que as novilhas atingem a puberdade, apresentam ciclos estrais em intervalos de 21 dias que só são interrompidos pela gestação ou por alguma patologia. O anestro patológico é raro em novilhas; no entanto, surgem casos de piometra e cistos luteinizados, que são tratados com uma dose de PGF2α. Também se observam anormalidades de desenvolvimen- to, tais como freemartinismo e hipoplasia genital, patologias que não têm tratamento; somente 8% das novilhas freemartin são férteis. O anestro funcional (as novilhas manifestam estro, mas não são detectadas) é frequen- te e está diretamente relacionado com a eficiência na detecção de estros. As novilhas com idade e peso para se integrarem no programa reprodutivo e não apresentarem sinais de estro devem ser examinadas retalmente para diagnosticar a causa do anestro. Se, durante a palpação retal, as novilhas tiverem um corpo lúteo são tratadas nesse momento com PGF2α, os animais sem corpo lúteo podem receber uma injeção de PGF2α, sete dias depois. Este programa sincroniza o estro e aumenta a probabilidade de o detectar (figura 11). -/- Figura 11: As novilhas com idade e peso para se integrarem no programa reprodutivo e não mostrarem sinais de estro devem ser verificadas via retal para diagnosticar a causa do anestro. Arquivo pessoal do autor. -/- 8. MANEJO DA NOVILHA INFÉRTIL -/- A fertilidade das vacas leiteiras diminuiu nos últimos 30 anos, enquanto a fertilidade das novilhas não se alterou; após a primeira inseminação, entre 60 e 70% das novilhas emprenham. O objetivo do programa reprodutivo é conseguir que 90% das novilhas gestem nos primeiros três serviços. Desta forma, esta proporção de animais daria à luz antes dos 25 meses de idade. É comum que 10% das novilhas se transformem em animais repetidores, ou seja, novilhas com mais de três serviços inférteis. A causa da falha na concepção de novilhas deve-se principalmente à morte embrionária precoce. Uma causa importante da falha na concepção das novilhas repetidoras são as patologias adquiridas no aparelho reprodutivo; é comum encontrar aderências ovarianas e salpingite. Provavelmente, esses problemas são consequência de alguma infecção adquirida durante a criação. Diversos tratamentos hormonais têm sido testados para resolver o problema de infertilidade em novilhas repetidoras e os resultados obtidos ainda são deficientes. Como estes tratamentos não apresentam resultados consistentes, a melhor forma de mitigar o problema de infertilidade nas novilhas é melhorando as práticas de inseminação, ou seja, o momento da inseminação, o manejo do sêmen e a técnica de inseminação empregada. Além disso, a melhor técnica para aumentar a proporção de novilhas prenhes no rebanho é aumentar a eficiência da detecção de estros. -/- 9. RESUMO -/- As novilhas devem parir aos dois anos de idade (23 a 25 meses). O peso ao parto deve ser de 550 a 580 kg. O manejo reprodutivo começa aos 14 ou 15 meses de idade, com um peso de 350 a 370 kg. As palhetas de sêmen sexado contêm de 2 a 3 milhões de espermatozoides. As doses de sêmen não sexado contêm de 20 a 30 milhões de espermatozoides. A porcentagem de concepção das novilhas inseminadas com sêmen sexado é 10 a 20% menor do que com sêmen não sexado. Com sêmen sexado se obtém entre 90 e 95% de fêmeas. A porcentagem de concepção com programas de IATF é de 20 a 35% menor que nas novilhas inseminadas no estro natural. Cerca de 90% das novilhas devem ficar prenhes nos primeiros três serviços. Devem ser produzidas novilhas para substituir as vacas que são descartadas anualmen- te (25 a 35%). Espera-se que um gado leiteiro tenha ao dispor uma população de animais de reposição, desde um dia de vida até a etapa de novilha ao parto, correspondente a, pelo menos, 70 % do total das vacas. -/- REFERÊNCIAS BIBLIOGRÁFICAS -/- AUAD, Alexander Machado et al. Manual de bovinocultura de leite. Brasília: LK Editora, 2010. BRICKELL, J. S.; MCGOWAN, M. M.; WATHES, D. C. Effect of management factors and blood metabolites during the rearing period on growth in dairy heifers on UK farms. Domestic animal endocrinology, v. 36, n. 2, p. 67-81, 2009. DE VRIES, A. et al. Exploring the impact of sexed semen on the structure of the dairy industry. Journal of Dairy Science, v. 91, n. 2, p. 847-856, 2008. Fertilidade em Vacas Leiteiras: Fisiologia e Manejo. Fisiologia do Estro e do Serviço na Reprodução Bovina. FERREIRA, A. M. Manejo reprodutivo de bovinos leiteiros: práticas corretas e incorretas, casos reais, perguntas e respostas. Edição do autor, Juiz de Fora, 2012. FERREIRA, A. de M. Reprodução da fêmea bovina: fisiologia aplicada e problemas mais comuns (causas e tratamentos). Juiz de Fora: Minas Gerais–Brasil, p. 422, 2010. GALINA, Carlos; VALENCIA, Javier. Reproducción de los animales domésticos. 2006. GONÇALVES, J. N. Manual do produtor de leite. Viçosa, MG: Aprenda Fácil, 2012. HEINRICHS, A. J. Raising dairy replacements to meet the needs of the 21st century. Journal of dairy science, v. 76, n. 10, p. 3179-3187, 1993. HOFFMAN, P. C. Optimum body size of Holstein replacement heifers. Journal of Animal Science, v. 75, n. 3, p. 836-845, 1997. NEIVA, R. S. Criação eficiente de bezerros e novilhas. Lavras: Autor, 2013. NEIVA, Rogério Santoro. Produção de bovinos leiteiros. Lavras: UFLA, 1998. PEREIRA, E. S. et al. Novilhas leiteiras. Graphiti Gráfica e Editora LTDA, Fortaleza, Ceará, 2010. CARVALHO, B. C. Manejo reprodutivo de novilhas leiteiras. In. SENAR. Curso de reprodução e genética em bovinocultura de leite. Coronel Pacheco: Senar, 2021. YOUNGQUIST, Robert S.; THRELFALL, W. R. Large animal theriogenology. 2007. (shrink)

1.Summary The key terms. 1. Key term: ‘Sunyata’. Nagarjuna (Kumarajiva) is known in the history of Buddhism mainly by his keyword ‘sunyata’. This word is translated into English by the word ‘emptiness’. The translation and the traditional interpretations create the impression that Nagarjuna (Kumarajiva) declares the objects as empty or illusionary or not real or not existing. What is the assertion and concrete statement made by this interpretation? That nothing can be found, that there is nothing, that nothing exists? Was (...) Nagarjuna (Kumarajiva) denying the external world? Did he wish to refute that which evidently is? Did he want to call into question the world in which we live? Did he wish to deny the presence of things that somehow arise? My first point is the refutation of this traditional translation and interpretation. 2. Key terms: ‘Dependence’ or ‘relational view’. My second point consists in a transcription of the keyword of ‘sunyata’ by the word ‘dependence’. This is something that Nagarjuna (Kumarajiva) himself has done. Now Nagarjuna’s (Kumarajiva’s) central view can be named ‘dependence of things’. Nagarjuna (Kumarajiva) is not looking for a material or immaterial object which can be declared as a fundamental reality of this world. His fundamental reality is not an object. It is a relation between objects. This is a relational view of reality. This is the heart of Nagarjuna’s (Kumarajiva’s) ideas. In the 19th century a more or less unknown Italian philosopher, Vincenzo Goberti, spoke about relations as the mean and as bonds between things. Later, in quantum physics and in the philosophy of Alfred North Whitehead we are talking about interactions and entanglements. These ideas of relatedness or connections or entanglements in Eastern and Western modes of thought are the main idea of this essay. Not all entanglements are known. Just two examples: the nature of quantum entanglements is not known. Quantum entanglements should be faster than light. That's why Albert Einstein had some doubts. A second example: the completely unknown connections between the mind and the brain. Other examples are mysterious like the connections between birds in a flock. Some are a little known like gravitational forces. 3. Key terms: ‘Arm in arm’. But Nagarjuna (Kumarajiva) did not stop there. He was not content to repeat this discovery of relational reality. He went on one step further indicating that what is happening between two things. He gave indications to the space between two things. He realized that not the behaviour of bodies, but the behaviour of something between them may be essential for understanding the reality. This open space is not at all empty. It is full of energy. The open space is the middle between things. Things are going arm in arm. The middle might be considered as a force that bounds men to the world and it might be seen as well as a force of liberation. It might be seen as a bondage to the infinite space. 4. Key term: Philosophy. Nagarjuna (Kumarajiva), we are told, was a Buddhist philosopher. This statement is not wrong when we take the notion ‘philosophy’ in a deep sense as a love to wisdom, not as wisdom itself. Philosophy is a way to wisdom. Where this way has an end wisdom begins and philosophy is no more necessary. A.N. Whitehead gives philosophy the commission of descriptive generalization. We do not need necessarily a philosophical building of universal dimensions. Some steps of descriptive generalization might be enough in order to see and understand reality. There is another criterion of Nagarjuna’s (Kumarajiva’s) philosophy. Not his keywords ‘sunyata’ and ‘pratityasamutpada’ but his 25 philosophical examples are the heart of his philosophy. His examples are images. They do not speak to rational and conceptual understanding. They speak to our eyes. Images, metaphors, allegories or symbolic examples have a freshness which rational ideas do not possess. Buddhist dharma and philosophy is a philosophy of allegories. This kind of philosophy is not completely new and unknown to European philosophy. Since Plato’s allegory of the cave it is already a little known. (Plato 424 – 348 Befor Current Era) The German philosopher Hans Blumenberg has underlined the importance of metaphors in European philosophy. 5. Key terms: Quantum Physics. Why quantum physics? European modes of thought had no idea of the space between two this. They were bound to the ideas of substance or subject, two main metaphysical traditions of European philosophical history, two main principles. These substances and these subjects are two immaterial bodies which were considered by traditional European metaphysics as lying, as a sort of core, inside the objects or underlying the empirical reality of our world. The first European scientist who saw with his inner eye the forces between two things had been Michael Faraday (1791-1867). Faraday was an English scientist who contributed to the fields of electromagnetism. Later physicists like Albert Einstein, Niels Bohr, Erwin Schrödinger, Werner Heisenberg and others followed his view in modern physics. This is a fifth point of my work. I compare Nagarjuna (Kumarajiva) with European scientific modes of thought for a better understanding of Asia. I do not compare Nagarjuna (kumarajiva) with European philosophers like Hegel, Heidegger, Wittgenstein. The principles and metaphysical foundations of physical sciences are more representative for European modes of thought than the ideas of Hegel, Heidegger and Wittgenstein and they are more precise. And slowly we are beginning to understand these principles. Let me take as an example the interpretation of quantum entanglement by the British mathematician Roger Penrose. Penrose discusses in the year of 2000 the experiences of quantum entanglement where light is separated over a distance of 100 kilometers and still remains connected in an unknown way. These are well known experiments in the last 30 years. Very strange for European modes of thought. The light should be either separated or connected. That is the expectation most European modes of thought tell us. Aristotle had been the first. Aristotle (384 - 322 Before Current Era) was a Greek philosopher, a student of Plato and a teacher of Alexander the Great. He told us the following principle as a metaphysical foundation: Either a situation exists or not. There is not a third possibility. Now listen to Roger Penrose: “Quantum entanglement is a very strange type of thing. It is somewhere between objects being separate and being in communication with each other” (Roger Penrose, The Large, the Small and the Human Mind, Cambridge University Press. 2000 page 66). This sentence of Roger Penrose is a first step of a philosophical generalization in a Whiteheadian sense. 6. Key terms: ‘The metaphysical foundations of modern science’ had been examined particularly by three European and American philosophers: E. A. Burtt, A.N. Whitehead and Hans-Georg Gadamer, by Gadamer eminently in his late writings on Heraclitus and Parmenides. I try to follow the approaches of these philosophers of relational views and of anti-substantialism. By ‘metaphysical foundations’ Edwin Arthur Burtt does not understand transcendental ideas but simply the principles that are underlying sciences. 7. Key terms: ‘Complementarity’, ‘interactions’, ‘entanglements’. Since 1927 quantum physics has three key terms which give an indication to the fundamental physical reality: Complementarity, interactions and entanglement. These three notions are akin to Nagarjuna’s (Kumarajiva’s) relational view of reality. They are akin and they are very precise, so that Buddhism might learn something from these descriptions and quantum physicists might learn from Nagarjuna’s (Kumarajiva’s) examples and views of reality. They might learn to do a first step in a philosophical generalisation of quantum physical experiments. All of us we might learn how objects are entangled or going arm in arm. [The end of the summary.]. (shrink)

Are the real numbers rich enough to measure intelligence? We generalize a result of Alexander and Hutter about the so-called Legg-Hutter intelligence measures of reinforcement learning agents. Using the generalized result, we exhibit a paradox: in one particular version of the Legg-Hutter intelligence measure, certain agents all have intelligence 0, even though in a certain sense some of them outperform others. We show that this paradox disappears if we vary the Legg-Hutter intelligence measure to be hyperreal-valued rather than real-valued.

Kant’s accounts of the Highest Good and the moral argument for God and immortality are central features of his philosophy. But both involve lingering puzzles. In this entry, we first explore what the Highest Good is for Kant and the role it plays in a complete account of ethical life. We then focus on whether the Highest Good involves individuals only, or whether it also connects with Kant’s doctrines about the moral progress of the species. In conclusion, we look into (...) three ways of articulating the moral argument for God and immorality that take our commitment to the Highest Good as their point of departure. (shrink)

The Molyneux question asks: would a blind person, who knows spheres and cubes only from touch, be able to recognize these shapes visually immediately upon becoming sighted, without touching them? Molyneux himself answered no. Locke accepted Molyneux’s negative answer. But Locke’s answer appears inconsistent with the doctrine of common sensibles, according to which some ideas are given in more than one sense modality. Motivated by alleviating this tension, philosophers have put forth several interpretations of Locke’s views on shape perception. Here (...) I motivate a novel interpretation of Locke that can better resolve the tension. (shrink)

In this paper, we analyse how GPS-based navigation systems are transforming some of our intellectual virtues and then suggest two strategies to improve our practices regarding the use of such epistemic tools. We start by outlining the two main approaches in virtue epistemology, namely virtue reliabilism and virtue responsibilism. We then discuss how navigation systems can undermine five epistemic virtues, namely memory, perception, attention, intellectual autonomy, and intellectual carefulness. We end by considering two possible interlinked ways of trying to remedy (...) this situation: [i] redesigning the epistemic tool to improve the epistemic virtues of memory, perception, and attention; and [ii] the cultivation of cognitive diligence for wayfinding tasks scaffolding intellectual autonomy and carefulness. (shrink)

The late tenth century siddha and scholar Ratnākaraśānti, also known as the Mahāsiddha Śāntipa, was renowned as the author of both philosophical śāstras and commentaries on tantra. Typically, these are considered separate spheres of activity. However, Ratnākaraśānti’s approach, building on the tradition of scholarship associated with the Mahāvairocanābhisaṃbodhitantra and the Guhyasamājatantra, as well as on Yogācāra analysis and Buddhist pramāṇa theory, is highly syncretic. This paper is a study of Ratnākaraśānti’s commentaries that highlights his synthesis of the exoteric and esoteric (...) streams of Buddhist discourse, with particular emphasis on the nondual nature of reflexive awareness (svasaṃvitti, rang rig), or 'luminosity' (prakāśa, gsal ba), which serves as the conceptual bridge between sūtra and tantra. (shrink)

The modern Everett interpretation of quantum mechanics describes an emergent multiverse. The goal of this paper is to provide a perspicuous characterisation of how the multiverse emerges making use of a recent account of (weak) ontological emergence. This will be cashed out with a case study that identifies decoherence as the mechanism for emergence. The greater metaphysical clarity enables the rebuttal of critiques due to Baker (2007) and Dawid and Th\'ebault (2015) that cast the emergent multiverse ontology as incoherent; responses (...) are also offered to challenges to the Everettian approach from Maudlin (2010) and Monton (2013). (shrink)

Unterrichtsreihe inklusive didaktischen Erläuterungen zur Problemfrage: Inwiefern befördert der Einsatz von Algorithmen bei Entscheidungsprozessen Diskriminierung?

This paper presents a novel understanding of the notion of calculability. In Gricean frameworks, calculability is defined in terms of how speakers can infer an implicature. The relevant inferences must e.g. be based on maxims of conversation or cooperation principles. Meanwhile, I suggest to define calculability in terms of when, or under which conditions, speakers can infer an implicature. An implicature is calculable if hearers can infer its existence even supposing that the implicature is not semantically encoded. This approach avoids (...) familiar challenges, including recently prominent challenges from pragmatic particularism. (shrink)

Skeptical invariantists maintain that the expression “knows” invariably expresses an epistemically extremely demanding relation. This leads to an immediate challenge. The knowledge relation will hardly if ever be satisfied. Consequently, we can rarely if ever apply “knows” truly. The present paper assesses a prominent strategy for skeptical invariantists to respond to this challenge, which appeals to loose talk. Based on recent developments in the theory of loose talk, I argue that such appeals to loose talk fail. I go on to (...) present a closely related, more promising response strategy, which combines assumptions about the dynamics of pragmatic presuppostions from Blome-Tillmann (2014) with an appeal to conversational exculpature, a phenomenon recently studied by Hoek (2018, 2019). (shrink)

In 1937 Joan Robinson proposed that “when capitalism is rightly understood, the rate of interest will be set at zero and the major evils of capitalism will disappear”. A permanent zero rate would abolish capitalist profit except in limited cases, leaving nearly all output to be claimed by labour as wages. It would allow capital to be allocated on the basis of prospective social benefit rather than short-term profitability and a collateral basis that favours the wealthy. It would remove some (...) of the economic pressure to use resources unsustainably. So why not do this? I argue that the few available philosophical arguments for positive interest rates are unsatisfactory. Those who want a just and sustainable form of capitalism should target net zero for the interest rate. (shrink)

Can there be grounding without necessitation? Can a fact obtain wholly in virtue of metaphysically more fundamental facts, even though there are possible worlds at which the latter facts obtain but not the former? It is an orthodoxy in recent literature about the nature of grounding, and in first-order philosophical disputes about what grounds what, that the answer is no. I will argue that the correct answer is yes. I present two novel arguments against grounding necessitarianism, and show that grounding (...) contingentism is fully compatible with the various explanatory roles that grounding is widely thought to play. (shrink)

A supplemental document for "Metalinguistic Gradability".

I argue that embodied understanding and conceptual-representational understanding interact through schematic structure. I demonstrate that common conceptions of these two kinds of understanding, such as developed by Wheeler (2005, 2008) and Dreyfus (2007a, b, 2013), entail a separation between them that gives rise to significant problems. Notably, it becomes unclear how they could interact; a problem that has been pointed out by Dreyfus (2007a, b, 2013) and McDowell (2007) in particular. I propose a Kantian strategy to close the gap between (...) them. I argue that embodied and conceptual-representational understanding are governed by schemata. Since they are governed by schemata, they can interact through a structure that they have in common. Finally, I spell out two different ways to conceive of the schematic interaction between them—a close, grounding relationship and a looser relationship that allows for a minimal interaction, but preserves the autonomy of both forms of understanding. (shrink)

I propose an approach to liar and Curry paradoxes inspired by the work of Roger Swyneshed in his treatise on insolubles (1330-1335). The keystone of the account is the idea that liar sentences and their ilk are false (and only false) and that the so-called ''capture'' direction of the T-schema should be restricted. The proposed account retains what I take to be the attractive features of Swyneshed's approach without leading to some worrying consequences Swyneshed accepts. The approach and the resulting (...) logic (called ''Swynish Logic'') are non-classical, but are consistent and compatible with many elements of the classical picture including modus ponens, modus tollens, and double-negation elimination and introduction. It is also compatible with bivalence and contravalence. My approach to these paradoxes is also immune to an important kind of revenge challenge that plagues some of its rivals. (shrink)

Thomas Schmidt argues that a widely held combination of views about reasons and ought—the Balancing View of Ought and the claim that reasons against Q are reasons for not-Q—is extensionally adequate only if it is complemented by two principles of reasons transmission. In this paper I present three problems for Schmidt’s package of views and two problems for his transmission principles considered in isolation. I then defend a rival package of views—a version of the Balancing View and the claim that (...) reasons against Q are reasons that bear on Q with negative weight—that avoids these problems and secures extensional adequacy without Schmidt’s principles. I conclude that friends of the Balancing View should prefer my package of views. (shrink)

Recently, Yudkowsky and Soares (2018) and Levinstein and Soares (2020) have developed a novel decision theory, Functional Decision Theory (FDT). They claim FDT outperforms both Evidential Decision Theory (EDT) and Causal Decision Theory (CDT). Yet FDT faces several challenges. First, it yields some very counterintuitive results (Schwarz 2018; MacAskill 2019). Second, it requires a theory of counterpossibles, for which even Yudkowsky and Soares (2018) and Levinstein and Soares (2020) admit we lack a “full” or “satisfactory” account. Here, I focus on (...) the latter problem of counterpossibles. My aim is to establish two claims. First, the problem of counterpossibles does not even arise without a fairly strong assumptionone that rarely applies to human agents, but may apply to artificial agents. And second, even given this assumption, the problem is solvable, though how best to solve it remains an open question. (shrink)

Dieser Beitrag setzt sich mit der unterrichtspraktischen Frage nach der Einführung und Vertiefung von Begriffsverständnissen im Philosophie- und Ethikunterricht auseinander. Als Ausgangspunkt dient dazu Sistermanns Bonbonmodell. Es wird dafür argumentiert, dass dieses Modell sowie die Leitidee der Problemorientierung erweitert werden sollten, so man dem Anspruch einer Vermittlung tiefgehender Begriffsverständnisse gerecht werden will. Um eine solche Erweiterung vorzuschlagen, werden erstens ein lernproduktorientiertes Lehr-Lern-Modell aus der Physikdidaktik und zweitens lernpsychologische Grundlagen, die als Darstellungsebenenwechsel in der Mathematikdidaktik Anwendung finden, hinzugezogen.

We have begun work on two separate but related ontologies for the study of neurological diseases. The first, the Neurological Disease Ontology (ND), is intended to provide a set of controlled, logically connected classes to describe the range of neurological diseases and their associated signs and symptoms, assessments, diagnoses, and interventions that are encountered in the course of clinical practice. ND is built as an extension of the Ontology for General Medical Sciences — a high-level candidate OBO Foundry ontology that (...) provides a set of general classes that can be used to describe general aspects of medical science. ND is being built with classes utilizing both textual and axiomatized definitions that describe and formalize the relations between instances of other classes within the ontology itself as well as to external ontologies such as the Gene Ontology, Cell Ontology, Protein Ontology, and Chemical Entities of Biological Interest. In addition, references to similar or associated terms in external ontologies, vocabularies and terminologies are included when possible. Initial work on ND is focused on the areas of Alzheimer’s and other diseases associated with dementia, multiple sclerosis, and stroke and cerebrovascular disease. Extensions to additional groups of neurological diseases are planned. The second ontology, the Neuro-Psychological Testing Ontology (NPT), is intended to provide a set of classes for the annotation of neuropsychological testing data. The intention of this ontology is to allow for the integration of results from a variety of neuropsychological tests that assay similar measures of cognitive functioning. Neuro-psychological testing is an important component in developing the clinical picture used in the diagnosis of patients with a range of neurological diseases, such as Alzheimer’s disease and multiple sclerosis, and following stroke or traumatic brain injury. NPT is being developed as an extension to the Ontology for Biomedical Investigations. (shrink)

What happens when scholars come together to study Buddhist and German Idealist perspectives on mind and representation? We explore this question and reflect on methodological considerations in what is often referred to as "comparative philosophy.".

Deleuze’ün Spinozacı yaşam tahayyülünde ‘ne yapmalıyız?’ sorusuna normatif, ahlaki ya da siyasi bir yanıt bulamıyoruz ama varoluşu düşünmenin içkin bir olanağını keşfediyoruz. Düşünmeye 'dışarıdan' yani dünyadan başlamak insani (kurgusal) bir dünyaya değil, içinde yaşadığımız gerçek dünyaya inanmak demektir. İçkinliğin politik anlamı düşünceyi dünyaya getirmektir.

Contrary to the popular assumption that linguistically mediated social practices constitute the normativity of action (Kiverstein and Rietveld, 2015; Rietveld, 2008a,b; Rietveld and Kiverstein, 2014), I argue that it is affective care for oneself and others that primarily constitutes this kind of normativity. I argue for my claim in two steps. First, using the method of cases I demonstrate that care accounts for the normativity of action, whereas social practices do not. Second, I show that a social practice account of (...) the normativity of action has unwillingly authoritarian consequences in the sense that humans act only normatively if they follow social rules. I suggest that these authoritarian consequences are the result of an uncritical phenomenology of action and the fuzzy use of “normative”. Accounting for the normativity of action with care entails a realistic picture of the struggle between what one cares for and often repressive social rules. (shrink)

In the history of philosophy, the distinction between positive and negative predication has been collapsed. The collapse has caused us to search for a way through Parmenides’ gate: we have constructed scaffolding to see over its boundaries. Kant gave us the distinction between conceptual and non-conceptual knowledge; Hegel gave us determinate negation; Frege gave us the negation stroke; Husserl gave us bracketing and disappointment; G. Spencer-Brown gave us a calculus of distinction. Despite this, we find ourselves—alongside Wittgenstein— wondering how it (...) can be the case that we are able to think what is not the case. We are puzzled by the fact that we can think nothing without the thought lacking content. I suggest that this confusion is unnecessary. Throughout this work, I exercise the thought that the distinction between positive and negative predication is mistaken. I rather suggest that to think what is or is not the case necessarily depends upon an exemplar distinction that is experientially recognized and learned in the world. All the same, our capacity to understand natural distinction likewise depends upon our practical and pervasively conceptual capacities to express it in language. I conclude by suggesting that what makes positive and negative predication distinct is a fundamental unity in conceptual form through its capacity to play distinct functional roles in linguistic practice. (shrink)

Ist es gerecht, dass familiärer Wohnraum in Deutschland ungleich verteilt ist? In sozio-ökonomisch schlecht aufgestellten Familien haben Kinder wenig (Wohn)Raum, um sich selbstbestimmt zu entwickeln. Anhand von Beispielen, die auf Prinzipien der Gerechtigkeit abzielen, lernen Schüler:innen, Probleme der Verteilung von Wohnraum wahrzunehmen und zu beurteilen.

The starting point of this article is the didactic question of the relationship between conceptual knowledge and competencies in the education of philosophy and ethics. Against the background of the philosophical debate on the conception of concepts, a conception of concepts as abilities is outlined. With this conception, in a first step, the disjunction between conceptual knowledge on the one hand and competencies on the other hand is dissolved. In a second step, a learningtheoretical framework of the formation of philosophical (...) concepts is developed through a critical examination of the so-called conceptual change. As a result, critical elucidation of concepts presents itself as a fundamental goal of ethics and philosophy teaching. (shrink)

Does natural science give us reason to believe that mathematical statements are true? And does natural science give us reason to believe in some particular metaphysics of mathematics? These two questions should be firmly distinguished. My argument in this chapter is that a negative answer to the second question is compatible with an affirmative answer to the first. Loosely put, even if science settles the truth of mathematics, it does not settle its metaphysics.

Discussion of the relevance of grounding to substantiveness, theory-choice, and “location problems” in metaphysics.